Indications

Ocular Surface Disease

Severe Dry Eye Disease/Dry Eye Syndrome

• Ocular chronic graft versus host disease (GVHD)
• Sjögren's syndrome
• History of LASIK or other refractive surgery

Limbal Stem Cell Deficiency

• Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis syndrome (TENS)
• Aniridia
• Cicatrical conjunctivitis/ ocular cicatrical pemphigoid
• Chemical/thermal injury

Epidermal Ocular Disorders

• Godenhar's syndrome
• Ectodermal dysplasia
• Atopy
• Epidermolysis bullosa

Neurotrophic Keratitis

• Congenital Corneal Anesthesia (CCA)
             • Familial dysautonomia
             • Trigeminal nerve dysfunction
             • Moebius syndrome
• Acquired Neurotrophic Keratitis
             • Herpes zoster (shingles)
             • Herpes simplex (ocular herpes)
             • Trigeminal nerve dysfunction
             • Post-surgical

Corneal Exposure/Lagophthalmos

• Anatomic
• Paralytic
• Acoustic neuroma

Corneal Ectasia/Irregular Astigmatism

Corneal Degenerations and Dystrophies

• Keratoconus
• Keratoglobus
• Pellucid marginal degeneration
• Terrien's marginal degeneration
• Salzmann’s nodular degeneration
• Meesmann’s corneal dystrophy (juvenile hereditary epithelial dystrophy)

Post Operative Astigmatism

• Cornea transplant (penetrating keratoplasty or PK, PKP)
• Radial keratotomy (RK)
• Photorefractive keratectomy (PRK)
• Phototherapeutic keratectomy (PTK)
• Epikeratophakia
• LASIK
• Open globe injury

Corneal Scarring

• After trauma
• After infection

For many of the thousands of patients with conditions such as Stevens-Johnson syndrome (SJS), chronic ocular graft-versus-host disease (GVHD), dry eye syndrome, Sjogren’s syndrome, keratoconus, pellucid marginal degeneration, ocular trauma, complications of LASIK, or complications of cornea transplantation, PROSE can be the ideal, and sometimes only, treatment capable of restoring vision and dramatically reducing symptoms such as eye pain, dry eye, blurry vision and light sensitivity.