Current Research Studies
Our research is guided by a single mission: improving patient quality of life. We help people living with complex corneal and ocular surface diseases and corneal irregularities find lasting comfort, visual clarity, and independence through care– built around their experience, informed by our research, and refined through decades of clinical learning.
BostonSight is the only clinical research provider with integrated access to a specialized patient population, manufacturing laboratory, dedicated research program, and established publication history — all under one roof. Our research is continuously informed by real patient needs, while our publications extend that expertise to clinical partners worldwide.
A Double-Masked, Randomized, Placebo-Controlled Study of the Safety, Tolerability, and Efficacy of d-MAPPS™ Ophthalmic Solution in the Treatment of Chronic Ocular Graft-Versus-Host Disease (oGVHD)
- Location of Study: BostonSight, Needham
- Study Status: Actively recruiting
- ClinicalTrials.gov ID # NCT06852768
The purpose of the clinical trial is to evaluate the safety, tolerability, and effectiveness of d-MAPPS ophthalmic solution, an eye drop used four times a day, in the treatment of chronic oGVHD.
Demodex Blepharitis in Scleral Lens Wearers
- Location of Study: BostonSight, Needham
- Study Status: Actively recruiting
The purpose of this study will be to see if Xdemvy (lotilaner ophthalmic solution) 0.25% has a positive impact on ocular surface symptoms and PROSE device functionality and performance. We hypothesize that the use of Xdemvy in subjects utilizing PROSE treatment will be well tolerated, and we hypothesize that the reduction in Demodex mite load on the eyelid margin will result in reduced ocular surface symptoms and improved PROSE tolerance and functionality.
The Effect of PROSE Treatment on Mental Health
- Location of Study: BostonSight, Needham
- Study Status: Actively recruiting
The goal of this prospective clinical trial is to evaluate the effect that PROSE treatment may have on mental health. Participants are required to be new patients, will complete standardized questionnaires, and will undergo a standard examination of the front surface of their eye.
Additional Local Clinical Research Studies
None at this time
Interested in Participating?
If you’re a current or prospective patient and would like to learn whether any of our active studies may be relevant to your care, talk to your BostonSight clinician or contact our research team.
Past Clinical
Research Studies
Novel Use of Restasis (Cyclosporine Ophthalmic Emulsion 0.05%) on the Application of PROSE Devices for Management of Patients with Ocular Surface Disease: A Pilot Study
- Location of Study: BostonSight, Needham
- Study Status: Completed
The purpose of this placebo/control study is to evaluate Restasis (cyclosporine ophthalmic solution 0.05%) when added to the PROSE (Prosthetic Replacement of the Ocular Surface Ecosystem) lens reservoir in patients with ocular surface disease (OSD).
This Study Is No Longer Recruiting
12-Week Clinical Study to Evaluate a New Investigational Eye Drop for Patients Who Have Ongoing Eye Pain/Dry Eye Symptoms and Have Had Refractive or Cataract Surgery
- Location of Study: BostonSight, Needham
- Study Status: Completed
This Study Is No Longer Recruiting
A Phase II/III Trial of Safety and Efficacy of Pro-ocular™ 1% in Daily Scleral Lens Wearing Patients with Ocular Graft-Versus-Host Disease
- Location of Study: BostonSight, Needham
- Study Status: Completed
The purpose of this placebo/control study is to evaluate the safety and efficacy of Pro-ocular™ 1% cream on reducing the signs and symptoms of Ocular Graft-Versus-Host Disease. Preliminary studies have shown success in reducing signs and symptoms in patients with Ocular Graft-Versus-Host Disease.
This Study Is No Longer Recruiting
An Evaluation of Tangible Boost (Hydra-PEG) at Home Lens Coating System for Patients with Dry Eye Syndrome, Steven Johnson Syndrome, Sjögren’s Syndrome, and Graft Versus Host Disease
- Location of Study: BostonSight, Needham
- Study Status: Completed
The purpose of this study is to evaluate the effectiveness of Tangible Boost, a product designed to provide the patient with a system to monthly re-coat their PROSE lenses with Hydra-PEG at home. Patients with Dry Eye Syndrome, Stevens-Johnson Syndrome, Sjogren’s Syndrome, or Graft versus Host disease are eligible. This study is for patients who are already using the Hydra-PEG coating or who are planning to get a new lens with Hydra-PEG coating.
This Study Is No Longer Recruiting
Pilot Study to Investigate the Feasibility, Reliability, and Efficiency of Utilizing Ocular Surface Optical Coherence Tomography to Automate PROSE Fitting
- Location of Study: BostonSight, Needham
- Study Status: Completed
The purpose of this study is to evaluate the feasibility, reliability and efficiency of utilizing ocular surface optical coherence tomography (ocular surface imaging) to automate the PROSE (Prosthetic Replacement of the Ocular Surface Ecosystem) fitting process. The use of this imaging technology could considerably reduce the time needed per visit, the number of visits, and the number of devices needed to be manufactured to reach the PROSE fitting endpoint.
This Study Is No Longer Recruiting
Measuring Eye Pressure in Patients Wearing Scleral Lenses
- Location of Study: BostonSight, Needham
- Study Status: Completed
The goal of this research is to determine how well we can measure intraocular pressure (“eye pressure”) when a scleral lens is on the eye. This prospective study uses three non-invasive FDA approved methods to measure eye pressure: scleral tonopen, scleral pneumatonometry, and Diaton tonometry. Evaluating these methods of measurement may be an important step for future studies investigating and understanding risk factors for glaucoma.
This Study Is No Longer Recruiting